Micronutrient supplementation affects DNA methylation in male gonads with potential intergenerational epigenetic inheritance involving the embryonic development through glutamate receptor-associated genes

Table 2 The number of DEGs, enriched KEGG pathways, and enriched GO terms

	n^a	DEG^b		KEGG^c	GO^d			GSEA^e
		Up	Down		BP	MF	CC	Up	Down
Gonads
L2:L1	5:6	3	3	0	0	0	0	7	2
L3:L1	6:6	60	37	0	0	0	0	2	7
Liver
L2:L1	6:6	72	57	2	10	8	0	0	4
L2:L1	6:6	153	146	8	36	16	6	0	15
G&L
L2:L1	12:12	75	30	0	3	0	0	5	4
L3:L1	11:12	196	150	3	10	0	0	2	22

^aNumber of samples represented as (# treatment group):(# control group). ^bNumber of DEGs defined by adjusted p-values < 0.1 and LFC > 0. ^cNumber of enriched KEGG pathways identified by ORA with adjusted p-values < 0.05 and the minimum gene count of 5. ^dNumber of enriched GO terms by ORA with adjusted p-values < 0.05 and the minimum gene count of 5. BP biological process, MF molecular function, and CC cellular component. ^eNumber of enriched KEGG pathways identified by GSEA with adjusted p-values < 0.05, minimum gene counts: 5 and abs(NES) > 2. Up & Down: the number of pathways enriched by up- and down-regulated genes, respectively

ISSN: 1471-2164