Micronutrient supplementation affects DNA methylation in male gonads with potential intergenerational epigenetic inheritance involving the embryonic development through glutamate receptor-associated genes

Table 6 Top three common DMGs in Exon150, P250, and P1K for gonads

Region	Gene symbol	Gene name	Ortholog^a	#DMCs^b
				Hypo	Hyper
Exon150	LOC106566321	potassium voltage-gated channel subfamily A member 2-like	KCNA2	0	3
	LOC106568430	putative uncharacterized protein DDB_G0286901	DDB_G0286901	0	2
	LOC106591755	nuclear pore complex protein Nup50-like	NUP50	0	1
P250	LOC106572512	glutamate receptor ionotropic, NMDA 3A-like	GRIN3A	2	0
	LOC106582681	dnaJ homolog subfamily C member 16-like	DNAJC16	1	1
	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	DEAD-box helicase 43	DDX43	1	0
P1K	LOC106611715	transmembrane protein 35-like	TMEM35A	3	0
	plcb4	phospholipase C beta 4	PLCB4	0	3
	LOC106578665	protein scribble homolog	SCRIB	2	0

^aHuman orthologues in UniProt (www.uniprot.org) except for DDB_G0286901, which is an orthologue of slime mold (Dictyostelium discoideum). ^bNumber of the DMCs for hypo-methylated (hypo) and hyper-methylated (hyper)

ISSN: 1471-2164