Fig. 1

Pairwise association of questionnaire variables and genetic markers. Significance test is shown above the diagonal line and effect size and direction below (odds ratio for categorical variables and estimate ratio for continuous variables). SNP alleles are given according to the CanFam3 nomenclature: Reference allele is A and Alternative is B (A/B should be considered arbitrary assignments without regard to population frequencies or ancestral/derived status). Genetic marker significance test and correlation are for AA vs BB. In the top right of the diagonal, light red denotes significant association, p ≤ 0.05; and dark red is significant association, p ≤ 0.001 (for actual p-values, see Suppl. Fig. S1). In the bottom left of the diagonal, red is positive association and blue negative. Values are colored in a gradient from red to blue according to their value. Only values with a significant association are displayed