Table 2 Gene-based analysis summary statistics of RCN3 in TOPMed Freeze 8 and UK Biobank: coding variants with MAF < 5%
From: Rare coding variants in RCN3 are associated with blood pressure
| Â | Â | PP | SBP | DBP | Â | Â | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | NVAR | Beta | Burden P | SKAT P | Beta | Burden P | SKAT P | Beta | Burden P | SKAT P |
TOPMed (discovery) | ||||||||||
 AA (N = 26,590) | 7 | 0.027 | 0.351 | 0.543 | −0.010 | 0.752 | 0.885 | −0.057 | 5.75 × 10−3 | 0.092 |
 EA (N = 15,284) | 3 | 0.008 | 0.694 | 0.833 | −0.033 | 0.228 | 0.411 | −0.082 | 6.85 × 10−4 | 4.34 × 10−3 |
 EAS (N = 3826) | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
 HA (N = 13,419) | 5 | −0.018 | 0.571 | 0.580 | −0.051 | 0.240 | 0.135 | −0.043 | 0.099 | 0.035 |
 Samoan (N = 1269) | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
 Trans-ancestry (N = 60,388) | 7 | 0.011 | 0.411 | 0.805 | −0.022 | 0.178 | 0.218 | − 0.051 | 1.36 × 10−5 | 8.11 × 10−5 |
UKB (replication) | ||||||||||
 African (N = 6937) | 4 | −0.124 | 0.004 | 0.007 | −0.249 | 5.90 × 10− 5 | 4.43 × 10− 4 | − 0.126 | 3.93 × 10− 4 | 0.005 |
 European (N = 386,813) | 4 | 0.021 | 0.004 | 0.006 | 0.034 | 5.80 × 10− 4 | 6.15 × 10− 4 | 0.013 | 0.018 | 0.011 |
 Asian (N = 9772) | 3 | −0.087 | 0.391 | 0.305 | −0.095 | 0.503 | 0.514 | −0.009 | 0.906 | 0.966 |