Table 3 Gene-based analysis summary statistics of RCN3 in TOPMed Freeze 8 and UK Biobank: non-coding variants with MAF < 1%

TOPMed (discovery)

 AA (N = 26,590)

267

7.52 × 10^− 4

0.774

0.262

0.003

0.268

0.837

−0.002

0.314

0.073

 EA (N = 15,284)

130

0.003

0.288

0.949

−1.68 × 10⁻⁴

0.967

0.969

0.004

0.299

0.496

 EAS (N = 3826)

51

0.020

0.294

0.469

0.021

0.386

0.279

4.38 × 10⁻⁴

0.980

0.323

 HA (N = 13,419)

189

−5.61 × 10⁻⁴

0.891

0.714

0.002

0.704

0.929

0.002

0.553

0.751

 Samoan (N = 1269)

30

0.063

0.318

0.148

0.200

0.049

0.090

0.123

0.079

0.296

 Trans-ancestry (N = 60,388)

267

0.002

0.200

0.902

2.72 × 10⁻⁴

0.880

0.984

−2.56 × 10^− 4

0.843

0.183

UKB (replication)

 African (N = 6937)

184

0.005

0.355

0.309

0.004

0.630

0.815

−1.31 × 10⁻³

0.762

0.488

 European (N = 386,813)

145

−1.03 × 10^− 3

0.407

2.97 × 10⁻⁴

−0.002

0.361

4.67 × 10⁻⁵

−7.97 × 10^− 4

0.387

0.017

 Asian (N = 9772)

65

0.014

0.029

0.024

0.015

0.088

0.126

0.001

0.868

0.889