Fig. 2

Regional spectra show differences between genomic regions. a Relative contribution of the indicated mutation types to the point mutation spectrum split between exons and the rest of the genome for each sample. The number of substitutions in each sample is indicated at the top of the figure. b Relative contribution of the indicated mutation types to the point mutation spectrum split between early-, intermediate-, and late-replicating DNA for each sample. The number of substitutions in each sample is indicated at the top of the figure. c Relative contribution of each trinucleotide change to the point mutation spectrum split between early- intermediate and late-replicating DNA for each sample. d A jitter plot depicting the presence of lesion segregation for each sample per chromosome. Each dot depicts a single base substitution. Any C > N or T > N is shown as a “+” strand mutation, while G > N and A > N mutations are shown on the “-“ strand. The x-axis shows the position of the mutations. The horizontal lines are calculated as the mean of the “+“ and “-“ strand, where “+“ equals 1 and “-” equals 0. They indicate per chromosome on which strand most of the mutations are located. The mutations were downsampled to 33% to reduce the file size