Fig. 3

Signature refitting is improved. a Absolute contribution of each mutational signature for each sample using “regular” signature refitting and b “strict” signature refitting. c Dot plot showing the contribution of each mutational signature for each sample using bootstrapped signature refitting. The colour of a dot indicates the fraction of bootstrap iterations in which a signature contributed to a sample. The size indicates the mean number of contributing mutations across bootstrap iterations in which the contribution was not zero. d Heatmap depicting the Pearson correlation between signature contributions across the bootstrap iterations. e Bar graph depicting the cosine similarity between the original and reconstructed profiles of each sample based on signature refitting