Fig. 5

Indel signatures can explain the MSH2 profile. a Relative contribution of each mutational signature for the wild-type (WT) and MSH2 samples using strict signature refitting. b Dot plot showing the contribution of each mutational signature for the WT and MSH2 samples using bootstrapped signature refitting. The color of a dot indicates the fraction of bootstrap iterations in which a signature contributed to a sample. The size indicates the mean number of contributing mutations across bootstrap iterations in which the contribution was not zero. c Bar graph depicting the cosine similarity between the original and reconstructed profiles of the WT and MSH2 samples based on signature refitting