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Fig. 5 | BMC Genomics

Fig. 5

From: DeepSARS: simultaneous diagnostic detection and genomic surveillance of SARS-CoV-2

Fig. 5

DeepSARS enables variant classification and the quantification of emerging mutations in the spike protein and receptor binding domain (RBD). A Depiction of SARS-CoV-2 spike protein regions targeted by the site-13, alpha-15 and spike-16 primer sets of DeepSARS. Red regions indicate primers present in either the site-13, alpha-15 or spike-16 primer set. Green regions represent those variant-defining mutations not currently targeted by DeepSARS. B Spike-based variant classification for publicly available whole genome sequencing data from GISAID at different time points during the pandemic. Spike protein variants were quantified using either sites covered by DeepSARS or all sites from whole genome sequencing data. C The fraction of mutations covered per spike protein using DeepSARS relative to whole genome sequencing. Error bars indicate standard error of mean. D The fraction of sequences containing one of three previously reported mutations of interest captured by DeepSARS

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