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Table 5 The frameshift substitution scores of the natural and alternative genetic codes

From: Frameshift and wild-type proteins are often highly similar because the genetic code and genomes were optimized for frameshift tolerance

Genetic codes (Number tested) Scoring Matrix FSS of the natural genetic code (NGC) FSS of the alternative genetic codes
FSS Score Rank Rank% STDEV STDEV% Average STDEV STDEV%
Random (1,000,000 × 100) PAM250 − 344 132,586.79 13.26% 1011.17 0.1011% − 504.88 0.54 −0.1073%
Blossum62 − 276 19,752.52 1.98% 295.17 0.0295% −450.53 0.27 −0.0598%
Gonnet250 −912 29,447.26 2.94% 398.72 0.0399% − 2872.95 4.16 −0.1447%
Compatible (13824) PAM250 −344 4273 30.91% −401.25
Blossum62 −276 481 3.48% −436.75
Gonnet250 −912 481 3.48% − 2736.13