Fig. 4

Some genes responsive to starvation in the intestine are also responsive to high fat feeding and microbial colonization. A Log2 fold changes for genes from 21dpS (X-axis) plotted according to their log2 fold changes in egg yolk-fed larval zebrafish compared to unfed controls (Y-axis), described in Zeituni et al [59]. Significantly differential genes only in starved zebrafish are plotted in blue, whereas genes significant in both datasets are plotted in red. Pearson’s correlation revealed a significant correlation between the two datasets (p < 0.05). B Log2 fold changes for genes from 21dpS (X-axis) plotted according to their log2 fold changes in zebrafish larvae colonized with a microbiome compared to germ-free controls (Y-axis), described in Davison et al [74]. Genes with significant log2 fold changes only in starved zebrafish are plotted in blue, whereas genes significant in both datasets are plotted in magenta. Pearson’s correlation did not reveal a significant correlation between the two datasets (p > 0.05)