Fig. 4

Examples of Mean Conservation Score and Open Chromatin Status Prediction versus Open Chromatin Conservation. a 7-week-old mouse cortex and striatum and macaque orofacial motor cortex (“Cortex”) and putamen (“Striatum”) open chromatin signal for a mouse brain OCR that is 50,328 bp away from the Stx16 transcription start site (TSS). Experimentally identified and predicted brain open chromatin statuses are conserved even though mean mouse PhastCons score is low. b 7-week-old mouse cortex and striatum and macaque orofacial motor cortex (“Cortex”) and putamen (“Striatum”) open chromatin signal for a mouse brain OCR that is 144,474 bp away from the Lnpk TSS. Experimentally identified and predicted brain open chromatin statuses are not conserved even though mean mouse PhastCons score is high. c Our mouse liver open chromatin, mouse liver H3K27ac ChIP-seq, and macaque liver open chromatin signal for a mouse liver OCR that is 24,814 bp away from the Rxra TSS. Experimentally identified and predicted liver open chromatin statuses are conserved even though mean mouse PhastCons score is low. d Our mouse liver open chromatin, mouse liver H3K27ac ChIP-seq, and macaque liver open chromatin signal for a mouse liver OCR that is 154,404 bp away from the Fn1 TSS. Experimentally identified and predicted liver open chromatin statuses are not conserved even though mean mouse PhastCons score is high. Animal silhouettes were obtained from PhyloPic [65]. Regions are mouse cortex or liver open chromatin peak summits ± 250 bp and their macaque orthologs, signals are from pooled reads across biological replicates, and liver H3K27ac ChIP-seq data was obtained from E-MTAB-2633 [40].