Table 3 Notable piRNA-targeted genes and clusters
From: Abundant small RNAs in the reproductive tissues and eggs of the honey bee, Apis mellifera
piRNAs upregulated in | Relative to | Gene ID (Beebase/Refseq) | Gene Name | Gene function |
|---|---|---|---|---|
Eggs, ovaries and spermatheca | Semen and testes | GB55060/LOC724287 | rhomboid related protein 3-like | The rhomboid superfamily of intramembrane serine proteases are involved in developmental patterning as well as mitochondrial fusion during spermatogenesis [89, 90]. |
Semen | Testes, eggs and ovaries | GB45868/LOC413081 | F-box/WD repeat-containing protein 7 | This gene is a homolog of archipelago in Drosophila, required for endocycles and mediates the negative regulation of cell growth by protein ubiquitination [91, 92] |
Semen | Spermatheca, ovaries, testes and eggs | GB54783/LOC408402 | Acetyl-coenzyme A transporter 1 | This gene is implicated in the developmentally regulated modification of O-acetylation of gangliosides in mammals [93] |
Ovaries, eggs and spermatheca | Semen and Testes | Cluster 20 | Sex determination locus | Genes implicated in sex determination in Apis mellifera including the complementary sex determiner and feminizer genes. |