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Fig. 5 | BMC Genomics

Fig. 5

From: RNA-seq coupling two different methods of castration reveals new insights into androgen deficiency-caused degeneration of submaxillary gland in male Sprague Dawley rats

Fig. 5

Transcriptomic analysis reveals the cause of SMG degeneration in androgen deprivation. (A) Hierarchical clustering analysis of the differentially expressed genes based on the z-score of their FPKM value. (B) Venn diagram of differentially expressed genes (DEGs) among groups. (C) Differentially expressed genes (DEGs) between ORC and EM. (D) Differentially expressed genes (DEGs) between IM and EM. (E) The common regulated genes in SMG by ORC and IM. (F-G) Functional enrichment analysis of the common downregulated and common upregulated DEGs, respectively using DAVID (6.8). Up, upregulated; Down, downregulated; NS, non-significant; MF, Molecular function; CC, Cellular component; BP, Biological process; KEGG, Kyoto encyclopedia of genes and genomes; EM, entire males; ORC, bilateral orchiectomy; IM, immunocastration

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