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Fig. 1 | BMC Genomics

Fig. 1

From: P. aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro

Fig. 1

Characterization of epithelial cells transcriptomic response to P. aeruginosa at one-hour post-infection. A The number of differentially regulated genes in P. aeruginosa PA14 infected epithelial cells compared to non-infected control. Only genes with a p-value ≤ 0.05, fold change > 2, and average FPKM difference > 7 were included in the analysis. B GO term analysis of “biological processes” enriched in P. aeruginosa PA14 infected A549 cells compared to non-infected control. (p ≤ 0.05). C Protein-protein interaction network of differentially regulated genes in A549 cells during P. aeruginosa infection compared to non-infected control. The node size positively correlates with the degree of connectivity. The color of the nodes correlates with the fold change of the corresponding genes. Genes associated with KEGG “MAPK signaling pathway”, “IL-17 signaling pathway” and “TNF signaling pathway” are circled in blue, green and red, respectively. Only nodes with connection are shown

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