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Fig. 2 | BMC Genomics

Fig. 2

From: P. aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro

Fig. 2

Immediate-early response genes in epithelial cells are upregulated upon P. aeruginosa infection. A Volcano plot of differentially expressed genes. Only genes with a p-value ≤ 0.05, fold change > 2, and average FPKM difference > 7 were analyzed as differentially regulated genes. Upregulated genes in response to PA14 compared to non-infected control are shown in red and down-regulated genes are shown in blue. Immediate-early response genes are outlined in black. Black proportion on the pie charts shows the percentage of immediate-early response genes in total differentially up or downregulated genes B Differentially regulated immediate-early response genes in P. aeruginosa PA14 infected epithelial cells with predicted upstream regulator function. Activation z-scores were calculated using IPA [24]. Only upstream transcriptional regulators with z-score > 2.0 or z-score < -2.0, and p-value < 0.01 are shown

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