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Fig. 5 | BMC Genomics

Fig. 5

From: P. aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro

Fig. 5

Activation of transcription factors and cytokine response in epithelial cells stimulated with T3SS, T6SS or parental strain of P. aeruginosa. RPKM values of A FOS and B EGR1 genes. C Transcription factor activation of nuclear extracts of epithelial cells incubated with P. aeruginosa PA14 (PA14), P. aeruginosa PA14::pscC (T3SS), and P. aeruginosa PA14 ΔHSI-II : : III (T6SS) and mock control. The values were represented as relative light units (RLU) normalized to ER (Estrogen Receptor). Cytokines D IL-6 and E IL-8 were quantified from supernatants of epithelial cells at 6 hrs post-infection. Kruskal Wallis test with Dunn’s multiple comparisons was performed for statistical analysis (**, p ≤ 0.01) F Graphical illustration of epithelial cell response to P. aeruginosa infection and the effect of injectosomes

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