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Table 1 Top 10 differentially up- and down-regulated protein-encoding genes in epithelial cells post-P. aeruginosa infection

From: P. aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro

Gene Symbol Official full name Fold change P value
EGR1 Early growth response 1 28.41 2.17 × 10–24
FOS Fos proto-oncogene, AP-1 transcription factor subunit 17.47 9.93 × 10–17
FOSB FosB proto-oncogene, AP-1 transcription factor subunit 7.39 1.05 × 10–5
SCG2 Secretogranin II 6.17 2.14 × 10–4
SLC6A15 Solute carrier family 6 member 15 4.59 1.01 × 10–4
NR4A2 Nuclear receptor subfamily 4 group A member 2 4.39 5.95 × 10–7
CCL20 C–C motif chemokine ligand 20 4.15 1.07 × 10–4
CRABP2 Cellular retinoic acid binding protein 2 4.10 8.12 × 10–7
ATF3 Activating transcription factor 3 3.51 1.02 × 10–5
IL6 Interleukin 6 3.50 3.65 × 10–3
IGFBP3 Insulin like growth factor binding protein 3 -2.27 4.71 × 10–6
VCAN Versican -2.30 4.91 × 10–8
ANXA8 Annexin A8 -2.32 3.62 × 10–4
FICD FIC domain protein adenylyltransferase -2.34 1.00 × 10–2
CRELD2 Cysteine rich with EGF like domains 2 -2.35 6.92 × 10–3
TM4SF4 Transmembrane 4 L six family member 4 -2.41 1.21 × 10–4
ASS1 Argininosuccinate synthase 1 -2.48 8.65 × 10–3
FRMD3 FERM domain containing 3 -2.65 3.74 × 10–4
TC2N Tandem C2 domains, nuclear -3.32 3.52 × 10–5
FAM25C Family with sequence similarity 25 member C -4.36 2.63 × 10–5