Table 4 Predicted upstream regulators of EGR1 and/or FOS genes in epithelial cells infected with P. aeruginosa. Selected upstream regulators were identified based on genes that were differentially regulated in epithelial cells after one hour infection with P. aeruginosa. Activation z-score shows predicted activation states of upstream regulators. The further the activation z-score from zero, the more likely that observed directionality of the target genes are consistent with the upstream regulator
| Upstream regulator | Activation z-score | P value |
|---|---|---|
| FOS | 2.33 | 6.33 × 10–13 |
| JUN | 2.555 | 2.73 × 10–15 |
| STAT3 | 3.553 | 1.71 × 10–14 |
| STAT1 | 2.207 | 6.38 × 10–7 |
| SP1 | 2.530 | 3.79 × 10–23 |
| CREB | 2.953 | 1.25 × 10–11 |
| HIF1A | 2.521 | 4.63 × 10–13 |
| EGR1 | 3.093 | 3.98 × 10–11 |