Fig. 2

Correlations of differences in gene expression between developmental ethanol treatment and control in males. The center panel heat map corresponds to the unfiltered, bi-clustered correlation matrix calculated for differences in expression of genes with a statistically significant line-by-ethanol treatment interaction term in a linear mixed effects model. The strength of the correlation is depicted as gradients and the directionality as color (positive correlations in red and negative correlations in blue). Networks derived from clusters with strong intra-connectivity are depicted around the center panel (panels A-I). The MCODE connectivity score for each node is represented as a color gradient. The edge colors follow the same scheme as the center panel (strength as gradient and directionality as color). Genes with statistically significant eQTLs are highlighted with pink borders