Table 1 Functional annotation of Smad2 and Smad3 bound genes in MCF10A-MII cells. RTK: receptor tyrosine kinase. ECM: extracellular matrix. NI: Non-integrin
From: Deep learning for de-convolution of Smad2 versus Smad3 binding sites
Early | Â | Late | Â |
|---|---|---|---|
Smad2 | Smad3 | Smad2 | Smad3 |
RTK signaling | RTK signaling | Neuronal System | RTK signaling |
ECM reorganization | ECM reorganization | ||
Extra-nuclear estrogen signaling | Signaling by TGF β members | cell-cell communication | ECM degradation |
Signaling by MET | Signaling by TGF β Receptor Complex | Cell junction organization | cell-cell communication |
NI membrane-ECM interactions | VEGFA-VEGFR2 Pathway | Netrin-1 signaling | NI membrane-ECM interactions |