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Fig. 3 | BMC Genomics

Fig. 3

From: Chromosomal localization of cohesin is differentially regulated by WIZ, WAPL, and G9a

Fig. 3

Distinct roles for WIZ, WAPL, and G9a in cohesin localization. A Depiction of differential occupancy analysis. ChIP-seq signal at peaks called in both WT and perturbation conditions is quantitatively compared, with sites showing significant increases or decreases in signal being called as differentially occupied. B Differential RAD21 signal analysis in Wizdel cells. Total percentage of differentially occupied retained sites is in parentheses in the panel title. Differential sites are colored orange. (C) Differential RAD21 signal analysis in WAPL-AID cells. Differential sites are colored purple. D Differential SMC3 signal analysis in G9a KO cells. Differential sites are colored green. E Comparison of change in cohesin ChIP-seq signal at differential sites identified in both Wizdel and WAPL-AID cells. The log2 fold change in cohesin signal at differential sites in Wizdel cells is colored orange. The log2 fold change in cohesin signal at differential sites in WAPL-AID cells is colored purple. The sites are sorted based on the signal in WAPL-AID cells. The sites which show an increase in ChIP-seq signal in both conditions appear in the teal quadrant. F Comparison of change in cohesin ChIP-seq signal at differential sites in both Wizdel and G9a KO cells. The log2 fold change in RAD21 signal at each site in Wizdel cells is colored orange. The log2 fold change in SMC3 signal at each site in G9a KO cells is colored green. The sites are sorted based on the signal in G9a KO cells. The sites which show an increase in ChIP-seq signal in both conditions appear in the teal quadrant

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