Fig. 4

Exploration of the gene features of MS-PRGenes and MAGMA genes. (A) Comparing the boxplots of pLI scores between MS-PRGenes and MAGMA genes in a two-sided t-test. (B) Comparing the boxplots of pLI scores within the closest gene and non-closest gene groups of MS-PRGenes in a two-sided t-test. (C) Comparing the boxplots of pLI scores within the 2SMR validated gene and 2SMR unvalidated gene groups of MS-PRGenes in a two-sided t-test. (D) Comparing the boxplots of evolutionary rates between MS-PRGenes and MAGMA genes in a two-sided t-test. (E) Comparing the boxplots of evolutionary rates within the closest gene and non-closest gene groups of MS-PRGenes in a two-sided t-test. (F) Comparing the boxplots of evolutionary rates within the 2SMR validated gene and 2SMR unvalidated gene groups of MS-PRGenes in a two-sided t-test. (G) The proportional comparison of MS-PRGenes and MAGMA genes overlapped with disease genes parsed from OMIM in the chi-squared test. (H) The proportional comparison of MS-PRGenes and MAGMA genes overlapped with known genes with disease-associated variants parsed from ClinVar in the chi-squared test