Fig. 5
From: Identification of condition-specific regulatory mechanisms in normal and cancerous human lung tissue
The merged triangle network of TFs from GRNs regulating both nodes in csGCN subnetwork edges. A The merged network for GTEx normal lung subnetwork mapped with GRN. B The merged network for TCGA LUAD subnetwork mapped with GRN. C The merged network for TCGA LUSC subnetwork mapped with GRN. Pink round nodes represent TFs, grey rectangular nodes represent genes that are both regulated by TFs and exist in each csGCN subnetworks. A line with an arrow indicates a directed edge and the line without arrow is the undirected edge. For lung cancer specific sub-networks, the name of up-regulated DEGs are shown in red; the name of down-regulated DEGs are shown in blue; non-DEGs were shown in black. GCN undirected edges are shown in grey. The directed edges when TF/TR ratio was different from normal to cancer are shown in orange, while directed edges when TF/TR ratio was not significantly different are shown as black