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Table 3 Genes Selected for Deeper Analysis

From: Identification of condition-specific regulatory mechanisms in normal and cancerous human lung tissue

Gene

Description

Condition

LUAD mutation ratea

LUSC mutation ratea

ETV1

ETS Variant Transcription Factor 1

LUAD

1.23%

1.82%

ETV4

ETS Variant Transcription Factor 4

LUAD

0.35%

0.61%

ETV6

ETS Variant Transcription Factor 6

LUAD

1.06%

2.63%

ELK4

ETS Transcription Factor ELK4

LUAD

0.88%

0.40%

LIMS2

LIM and senescent cell antigen-like domains 2

LUAD

0.71%

1.62%

ILVBL

IlvB Acetolactate Synthase Like Protein

LUAD

0.71%

1.41%

ABCC5

ATP Binding Cassette Subfamily C Member 5

LUAD

3.88%

4.65%

PSMA4

proteasome 20S subunit alpha 4

LUSC

0.71%

1.21%

PSMC5

proteasome 26S subunit, ATPase 5

LUSC

0.88%

0.61%

E2F1

E2F transcription factor 1

LUSC

0.53%

0.81%

MCM5

Minichromosome Maintenance Complex Component 5

LUSC

2.65%

2.63%

GINS1

GINS Complex Subunit 1

LUSC

0.35%

0.81%

GINS2

GINS Complex Subunit 2

LUSC

0.35%

–

CDC45

Cell Division Cycle 45

LUSC

0.71%

1.62%

RFC4

Replication Factor C Subunit 4

LUSC

1.41%

2.42%

RFC5

Replication Factor C Subunit 5

LUSC

0.88%

1.21%

PRIM1

DNA Primase Subunit 1

LUSC

0.53%

2.02%

PCNA

Proliferating Cell Nuclear Antigen

LUSC

0.18%

0.61%

SPC25

SPC25 Component Of NDC80 Kinetochore Complex

LUSC

0.53%

0.20%

SFTA3

Surfactant Associated 3

LUSC

0.71%

0.61%

SFTPA2

Surfactant Protein A2

LUSC

0.53%

2.22%

SFTPB

Surfactant Protein B

LUSC

1.59%

1.21%

SFTPD

Surfactant Protein D

LUSC

0.71%

1.01%

  1. a Mutation rates are the percent cases with simple somatic mutations on the target gene