Fig. 4
From: Maternal age affects equine day 8 embryo gene expression both in trophoblast and inner cell mass
GSEA clustering of the most perturbed terms in ICM and TE according to mares’ age. Nodes represent altered gene sets in ICM and TE (FDR < 0.05). Node size represents the gene set size. Node shape represents the gene set database: GO BP (circle) or KEGG (diamond). YM was the reference group: blue nodes represent enriched gene sets in YM (NES < 0) while red nodes represent enriched gene sets in OM (NES > 0). Edges represent the level of connection between representative gene sets. This graph was performed using SUMER R package [40] and modified using cytoscape 3.8.2 [41]. ICM: Inner Cell Mass; TE: trophoblast; FDR: False Discovery Rate; GO BP: Gene Ontology Biological Process; Kyoto Encyclopedia of Genes and Genomes; NES: Normalized Enrichment Score; YM: Young mares; OM: Old mares