Fig. 2
From: Psychiatric manifestations of rare variation in medically actionable genes: a PheWAS approach
PheWAS of rare variation in CACNA1C (A) and TCF4 (B) with 37 psychiatric disorders. Findings from burden tests that assess the enrichment of each variant category in psychiatric disorders are depicted; x-axis shows the -log10(p-value) across all 37 psychiatric conditions on the y-axis. An upright triangle indicating a risk-increasing effect (OR > 1) of the tested variant class and an inverted triangle indicating a risk-decreasing association (OR < 1). The vertical dotted grey line represents the nominal significance level of 0.05, and the vertical red solid line represents the Bonferroni-corrected significance (1.35 × 10–3). No association surpassed the study-wide significance at FDR < 0.05