Fig. 4

GDA analysis of the Plasmodium vivax P01 and P. knowlesi H genomes. A The P. vivax genome neatly separates into two clusters with seq + rep + gene + orth feature sets. B These represent core (magenta) and subtelomeric (cyan) regions. C The clusters are typified, amongst other things, by having one-to-one orthologous genes versus highly paralogous species-specific genes, respectively. In the heatmap colours indicate the relative value of the feature in each cluster (red = highest, blue lowest), icons indicate significance (‘∧’ = KS test greater p-value <  = 1e-20, ‘∨’ = KS test lesser p-value <  = 1e-20, ‘-’ = great and lesser p-values <  = 1e-20). D P. knowlesi separated into four clusters. E None of the clusters were localised to the subtelomeres. F The cluster with large species-specific gene families equivalent to the subtelomeric cluster of P. vivax (cluster 1; green) is dispersed throughout each chromosome