Maternal dietary methionine restriction alters the expression of energy metabolism genes in the duckling liver

Sécula, Aurélie; Chapuis, Hervé; Collin, Anne; Bluy, Lisa E.; Bonnet, Agnès; Bodin, Loys; Gress, Laure; Cornuez, Alexis; Martin, Xavier; Bonnefont, Cécile M. D.; Morisson, Mireille

doi:10.1186/s12864-022-08634-1

BMC Genomics

Table 1 Differentially expressed genes (DEGs) in the liver of ducklings

From: Maternal dietary methionine restriction alters the expression of energy metabolism genes in the duckling liver

GENE	R group	C group	Females	Males	Diet	Sex	Sex*Diet
	LsMeans ± SD	LsMeans ± SD	LsMeans ± SD	LsMeans ± SD	P-value (BH)	P-value (BH)	P-value (BH)
*GPAM*	0.39 ± 0.16	− 0.52 ± 0.17	− 0.59 ± 0.17	0.47 ± 0.15	< 0.01	< 0.01	0.28
NDUFA4	− 0.61 ± 0.19	0.64 ± 0.19	− 0.02 ± 0.2	0.05 ± 0.18	< 0.01	0.98	0.99
*PGM1*	0.53 ± 0.15	− 0.65 ± 0.15	− 0.53 ± 0.16	0.41 ± 0.14	< 0.01	< 0.01	0.78
COX2	− 0.55 ± 0.24	0.77 ± 0.28	0.01 ± 0.26	0.2 ± 0.25	0.01	0.93	0.85
*ELOVL6*	0.51 ± 0.27	− 0.5 ± 0.31	− 0.46 ± 0.26	0.47 ± 0.25	0.01	< 0.01	0.92
ENO1	−0.54 ± 0.24	0.51 ± 0.27	−0.1 ± 0.25	0.07 ± 0.23	0.01	0.81	0.85
MTTP	−0.48 ± 0.21	0.55 ± 0.22	0.1 ± 0.23	−0.02 ± 0.2	0.01	0.87	1.00
PGK1	0.49 ± 0.25	−0.46 ± 0.27	−0.29 ± 0.25	0.32 ± 0.23	0.01	0.07 *	0.29
*PRKAA1*	−0.49 ± 0.2	0.4 ± 0.2	−0.48 ± 0.21	0.39 ± 0.19	0.01	0.02	0.83
RXRA	−0.78 ± 0.3	0.51 ± 0.24	−0.77 ± 0.31	0.49 ± 0.23	0.01	0.11	1.00
UGDH	0.48 ± 0.21	−0.53 ± 0.22	−0.2 ± 0.22	0.15 ± 0.2	0.01	0.42	0.83
CYTB	−0.6 ± 0.28	0.52 ± 0.33	−0.15 ± 0.29	0.07 ± 0.27	0.02	0.54	0.70
BCL2A1	0.34 ± 0.21	−0.43 ± 0.21	−0.33 ± 0.22	0.25 ± 0.2	0.03	0.13	0.70
NDUFB6	−0.4 ± 0.22	0.42 ± 0.22	−0.08 ± 0.23	0.1 ± 0.21	0.03	0.81	0.70
PPARG	0.47 ± 0.22	−0.5 ± 0.24	−0.1 ± 0.23	0.07 ± 0.22	0.03	0.81	0.87
PPARGC1B	−0.43 ± 0.23	0.43 ± 0.23	0 ± 0.23	0 ± 0.22	0.03	0.98	0.87
BMF	−0.48 ± 0.3	0.46 ± 0.34	−0.27 ± 0.3	0.25 ± 0.29	0.06 *	0.18	0.78
PPARA	−0.35 ± 0.22	0.33 ± 0.22	−0.29 ± 0.23	0.27 ± 0.21	0.10 *	0.23	0.79
*ELAVL1*	0.2 ± 0.24	−0.35 ± 0.28	−0.67 ± 0.24	0.53 ± 0.24	0.22	< 0.01	0.99
*HMGCR*	0.1 ± 0.33	− 0.25 ± 0.37	−0.67 ± 0.32	0.51 ± 0.31	0.47	< 0.01	0.12
*MEF2C*	0 ± 0.19	− 0.12 ± 0.19	−0.71 ± 0.2	0.59 ± 0.18	0.75	< 0.01	1.00
*SCD1*	0.32 ± 0.26	− 0.44 ± 0.31	−0.52 ± 0.26	0.4 ± 0.26	0.10	< 0.01	0.70
*TALDO1*	0.31 ± 0.25	− 0.37 ± 0.29	−0.58 ± 0.25	0.51 ± 0.24	0.10	< 0.01	0.70
*VLDLR*	−0.23 ± 0.3	0.01 ± 0.34	0.58 ± 0.29	−0.8 ± 0.29	0.66	< 0.01	0.99
*PCK1*	−0.28 ± 0.31	0.1 ± 0.35	0.36 ± 0.31	−0.54 ± 0.3	0.47	0.01	0.85
*FASN*	0.28 ± 0.27	−0.38 ± 0.31	−0.43 ± 0.27	0.33 ± 0.26	0.14	0.02	0.08
*MAPK1*	0.19 ± 0.3	−0.38 ± 0.35	−0.57 ± 0.31	0.38 ± 0.29	0.32	0.02	0.85
*ABCA1*	0.05 ± 0.29	−0.27 ± 0.32	−0.54 ± 0.29	0.32 ± 0.28	0.55	0.04	0.84
*DGAT2*	0.06 ± 0.24	−0.12 ± 0.24	−0.49 ± 0.24	0.43 ± 0.23	0.71	0.04	0.85
ALDOB	−0.34 ± 0.25	0.36 ± 0.28	0.36 ± 0.26	−0.35 ± 0.24	0.13	0.06 *	0.85
SDHA	−0.24 ± 0.22	0.16 ± 0.24	−0.45 ± 0.24	0.37 ± 0.22	0.35	0.06 *	0.85
DHCR24	0.11 ± 0.2	−0.15 ± 0.2	−0.37 ± 0.21	0.33 ± 0.2	0.44	0.07 *	0.08
HADH	−0.32 ± 0.23	0.21 ± 0.23	−0.44 ± 0.25	0.33 ± 0.21	0.30	0.07 *	0.83
LDHA	−0.13 ± 0.37	0.01 ± 0.43	0.26 ± 0.37	−0.38 ± 0.35	0.86	0.07 *	0.28

Genes are listed according to whether they are differentially expressed for maternal diet (first part of the table) or for duckling sex (second part of the table and/or in bold). The corrected P-value with Benjamini-Hochberg (BH) procedure of the diet effect, the sex effect and their interaction are presented
The star (*) indicates genes with a P-value (BH) between 0.05 and 0.1. For each gene, least square means (Ls-Means) and standard deviations (SD) are presented for the two maternal diet groups (R group and C group) and for both sexes

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