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Table 3 Summary of QTLs detected in GWAS and candidate genes associated with body reserves and body reserves dynamics

From: Genome-wide analyses reveal a strong association between LEPR gene variants and body fat reserves in ewes

Traita

Chr

Nb SNPsb

Top SNPc

Position (bp)

-log10(P-value)

SNP effectd

Closest genee

BCS-Pb

1

3

OAR1_40030112.1

38,809,812

6.55

3.7

PGM1

BCS-L

1

1

OAR1_40030112.1

38,809,812

5.87

3.3

PGM1

BCS-Pa

1

2

s30054.1

40,524,081

5.60

2.7

DNAJC6

BCS-Sa

1

3

oar3_OAR1_40821987

40,821,987

6.06

2.8

LEPR

BCS-Pb

1

7

oar3_OAR1_40,857,869

40,857,869

6.90

3.5

LEPR

BCS-L

1

11

oar3_OAR1_40890859

40,890,859

7.44

3.9

LEPR

BCS-Pb

1

2

OAR1_42228129.1

42,228,129

6.03

2.9

MIER1

BCS-Sb

2

1

OAR2_204233702.1

192,716,355

5.51

2.5

MYO1B, STAT1

BCS-Pa:W

3

1

OAR3_115100887.1

115,100,887

5.24

2.4

SYT1

BCS-Pb

8

1

s48527.1

13,120,875

4.84

2.0

TPD52L1

BCS-Pa

10

1

OAR10_9706403.1

11,281,919

5.00

2.0

PCDH8

BCS-Pa

15

1

OAR15_26097184.1

24,911,875

4.82

2.3

NXPE4

BCS-Sa

15

1

OAR15_87285774.1

78,544,042

5.22

2.3

OR10W1

BCS-Sa

15

1

OAR15_87912118.1

87,912,118

4.65

2.2

BCS-W:Wp

16

2

OAR16_33763548.1

31,368,878

6.59

2.6

CCL28

BCS-W:Wp

16

1

OAR16_34857607.1

34,857,607

4.99

1.9

DAB2

BCS-Pa:L

16

1

OAR16_46544413.1

42,819,279

5.03

2.0

CDH6

BCS-Sa

17

1

s70069.1

14,052,727

4.47

2.3

FREM3, GAB1

BCS-L

18

1

OAR18_31578626.1

30,304,217

4.65

2.4

NRG4

BCS-M:Pa

22

1

OAR22_24239807.1

24,239,807

4.39

1.9

SORCS3

BCS-Pa:L

24

1

OAR24_22245800.1

20,494,588

4.20

1.9

HS3ST2

BCS-W:Wp

25

1

s68395.1

32,693,219

4.43

1.6

KCNMA1

BCS-Pa

25

1

OAR25_39067458.1

37,133,591

4.75

2.5

  1. a BCS, Body Condition Score; M, Mating; Pa, Early pregnancy; Pb, Two-thirds pregnancy; L, Lambing; Sa, Early suckling; Sb, End of suckling; W, Weaning; Wp, Post-weaning period
  2. bNumber of significant SNPs in the 1-Mb window
  3. cThe reported top SNPs are SNPs that have the highest –log10 (P-value) among the significant SNPs that are in 1-Mb windows. SNPs for which –log10 (P-value) reached the genome-wide significance threshold (> 5.98) are reported in bold; the other reported SNPs reached the chromosome-wide significance threshold
  4. dPercentage of variance explained by SNP
  5. eAnnotated protein coding genes closest to the top SNP of the QTL region. Chr, chromosome