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Table 3 Summary of QTLs detected in GWAS and candidate genes associated with body reserves and body reserves dynamics

From: Genome-wide analyses reveal a strong association between LEPR gene variants and body fat reserves in ewes

Traita Chr Nb SNPsb Top SNPc Position (bp) -log10(P-value) SNP effectd Closest genee
BCS-Pb 1 3 OAR1_40030112.1 38,809,812 6.55 3.7 PGM1
BCS-L 1 1 OAR1_40030112.1 38,809,812 5.87 3.3 PGM1
BCS-Pa 1 2 s30054.1 40,524,081 5.60 2.7 DNAJC6
BCS-Sa 1 3 oar3_OAR1_40821987 40,821,987 6.06 2.8 LEPR
BCS-Pb 1 7 oar3_OAR1_40,857,869 40,857,869 6.90 3.5 LEPR
BCS-L 1 11 oar3_OAR1_40890859 40,890,859 7.44 3.9 LEPR
BCS-Pb 1 2 OAR1_42228129.1 42,228,129 6.03 2.9 MIER1
BCS-Sb 2 1 OAR2_204233702.1 192,716,355 5.51 2.5 MYO1B, STAT1
BCS-Pa:W 3 1 OAR3_115100887.1 115,100,887 5.24 2.4 SYT1
BCS-Pb 8 1 s48527.1 13,120,875 4.84 2.0 TPD52L1
BCS-Pa 10 1 OAR10_9706403.1 11,281,919 5.00 2.0 PCDH8
BCS-Pa 15 1 OAR15_26097184.1 24,911,875 4.82 2.3 NXPE4
BCS-Sa 15 1 OAR15_87285774.1 78,544,042 5.22 2.3 OR10W1
BCS-Sa 15 1 OAR15_87912118.1 87,912,118 4.65 2.2
BCS-W:Wp 16 2 OAR16_33763548.1 31,368,878 6.59 2.6 CCL28
BCS-W:Wp 16 1 OAR16_34857607.1 34,857,607 4.99 1.9 DAB2
BCS-Pa:L 16 1 OAR16_46544413.1 42,819,279 5.03 2.0 CDH6
BCS-Sa 17 1 s70069.1 14,052,727 4.47 2.3 FREM3, GAB1
BCS-L 18 1 OAR18_31578626.1 30,304,217 4.65 2.4 NRG4
BCS-M:Pa 22 1 OAR22_24239807.1 24,239,807 4.39 1.9 SORCS3
BCS-Pa:L 24 1 OAR24_22245800.1 20,494,588 4.20 1.9 HS3ST2
BCS-W:Wp 25 1 s68395.1 32,693,219 4.43 1.6 KCNMA1
BCS-Pa 25 1 OAR25_39067458.1 37,133,591 4.75 2.5
  1. a BCS, Body Condition Score; M, Mating; Pa, Early pregnancy; Pb, Two-thirds pregnancy; L, Lambing; Sa, Early suckling; Sb, End of suckling; W, Weaning; Wp, Post-weaning period
  2. bNumber of significant SNPs in the 1-Mb window
  3. cThe reported top SNPs are SNPs that have the highest –log10 (P-value) among the significant SNPs that are in 1-Mb windows. SNPs for which –log10 (P-value) reached the genome-wide significance threshold (> 5.98) are reported in bold; the other reported SNPs reached the chromosome-wide significance threshold
  4. dPercentage of variance explained by SNP
  5. eAnnotated protein coding genes closest to the top SNP of the QTL region. Chr, chromosome