Table 4 Categories and number of transcripts related to genes involved in innate immunity and/or antiviral defence up and down-regulated (p-value ≤ 0.01) by ocean acidification in the olfactory rosette of F2 European Sea Bass (Dicentrarchus labrax) juveniles

PRRs

109

nlrc3; nlrc5; nlrp1b; nlrp4e; trpm2; nod2; nwd1; spry2; spry3

pathogen recognition receptor; intracellular signal transduction [67, 68]

8

illr3; cd209; c209d

pathogen recognition receptor/sensing RNA viruses [69]

6

tlr1l; tlr2-1; tlr21; tlr22; tlr3; tlr9

pathogen recognition receptor/sensing RNA viruses [70,71,72]

1

ifih1

pathogen recognition receptor/sensing RNA viruses [73]

ISG

36

gimap7; gimap4; gimap8

secretion of cytokines; anti-apoptosis of lymphocytes [74]

9

gvinp1

Host resistance [75, 76]

1

mx

antiviral effector; inhibition of viral replication [77,78,79,80]

1

ifit2

inhibition of viral translation and replication [81, 82]

13

Nd

immunomodulator; antigen presentation [83,84,85]

30

trim2,9,25,32,33; bty; btr01,06; mid2

Sensors, restriction factors of viruses, regulators of IFN response [86, 87]

12

pkr1; prkrir; eif2ak2; thap4, 7; pak3,4

inhibition of viral translation and replication [88]

4

samhd1

Inhibition of viral replication [89]

1

sp100

inhibition of viral replication [88]

4

apo1; apol3

Degradation of the virus [88, 90, 91]

1

dram1

Degradation of the virus [86, 88, 92]

2

casp1; casp7

apoptosis effector [88]

3

stat5.1; stat6; Jak2

regulation of ISG expression [90, 93]

22

il17a/f-1; il20; il34; il1r1; il20ra; il6st

inflammation, protection against infection [94,95,96]

15

c1ql2; c1ql4l; c1qtnf1; tnfsf15; cd40

inflammation [97]

7

mavs; myd88; traf3; irf4; irf5; irf6; irf8

regulation of ISG expression [98,99,100]

101

rps2, 12, 14; wdr12; rpf2; nip7; eif4; eif4ebp3l; eif4a3; eif4ea; eif4b

inflammation, viral translation [98,99,100]