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Fig. 1 | BMC Genomics

Fig. 1

From: Accurate reconstruction of viral genomes in human cells from short reads using iterative refinement

Fig. 1

The ASPIRE method for reconstructing viral genomes. The basic pipeline (a) includes contig assembly, scaffolding, tiling, and gap filling. The iterative refinement procedure involves repeated alignment of scaffolds to the latest version of the reconstructed viral genome followed by gap filling (b) and a correction step based on allele frequencies derived from read alignments (c)

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