Transcriptomic analysis provides insights into molecular mechanisms of thermal physiology

BMC Genomics

Table 5 Brain Significant Module Trait Correlations

Trait	Module	Correl coef	FDR P-value	Hub GS	GS	Positive GS
body mass 12 °C	ME1_brain	-0.60	5.75E-04	MAP3K5	0.61	44.80%
body mass 28 °C	ME3_brain	0.58	1.46E-03	LOC105919139	0.63	68.70%
CT_max 28 °C	ME2_brain	-0.60	2.01E-04	CIAO2B	0.36	44.90%
CT_max 28 °C	ME3_brain	-0.57	4.83E-04	RAD17	0.64	83.90%
CT_max 28 °C	ME4_brain	-0.67	2.38E-05	APOC1	-0.65	48.60%
WAM 28 °C	ME4_brain	-0.70	3.15E-06	APOC1	-0.68	50.00%
	AVERAGE	0.62

Significant brain versus ME correlations with FDR p < 0.05. Columns include: Trait = traits significantly correlated with a given ME (critical thermal maximum: CT_max, whole animal metabolic rate: WAM), Module = identifier for module eigengene (ME, first principal component of module), Correl coef = Pearson’s signed correlation coefficient for trait and ME, FDR P-value = multiple test corrected p-value for trait versus module correlation, Hub GS = mRNA with highest gene significance for the trait in the module, GS = gene significance, correlation between top module mRNA and trait, Positive GS = proportion of mRNAs in the module that are positively correlated with trait

ISSN: 1471-2164