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Table 3 Summary of QTL detected for weaning weight in U.S. Red Angus cattle

From: Genome-wide association and genotype by environment interactions for growth traits in U.S. Red Angus cattle

Chr_Mba

-log10 P-value

Regression Beta

MAFb

Supporting SNPsc

Positional Candidate Genes

Lead SNP Location

Scientific Precedence [reference]; organism; trait

6_38

25.669

−10.153

0.283

66

LCORL, LOC782905

Intergenic

[20, 24, 26, 37,38,39,40,41,42,43,44,45]; Cattle; Birth, weaning and yearling weight, fat and protein percentage, carcass weight, fat thickness, dystocia, average daily gain and dry matter intake, hip height, ribeye area, calving ease, stature, feed intake and gain

6_37

21.575

−8.352

0.328

121

FAM184B

Intron

[20, 24, 39, 40, 42]; Cattle; Weaning and yearling weights, calving ease, dystocia, average daily gain, dry matter intake, daily feed intake

20_05

21.392

−7.859

0.444

94

LOC104975192, STC2

Intergenic

[20, 24, 31, 40, 42, 47, 48]; Cattle; Birth, weaning and carcass weight, average daily gain, dry matter intake, stature, mature rate, mid-test metabolic weight

6_36

16.846

− 9.442

0.219

30

HERC6

Intron

[20, 40, 42, 49,50,51]; Cattle; Birth, weaning, and yearling weight, mature weight, average daily gain, dry matter intake, backfat thickness, conception rate, milk production traits, protein ubiquitination

6_35

11.962

−5.632

0.356

26

LOC112447052

Intron

[24, 40, 43, 56]; Cattle; Birth weight, dry matter intake, fetal growth, weaning weight

20_06

10.817

− 5.963

0.385

7

NSG2

3’UTR

[40, 48, 49, 54, 73]; Cattle, mouse; Fat percentage, dry matter intake, mature weight, conception rate, synapse formation and maintenance

14_23

10.334

7.667

0.110

47

LOC112449630, MOS

Intergenic

[11, 20, 24, 26, 46]; Cattle; Birth, yearling and carcass weights, milk protein and fat yield, stature

6_34

8.719

− 5.723

0.286

21

CCSER1

Intron

[20, 49, 58, 65]; Cattle, human, sheep; Birth and weaning weight, conception rate, regulator of mitosis, feed intake

6_39

8.370

−5.285

0.270

21

LOC782905, SLIT2

Intergenic

[20, 24, 37, 40, 42, 52]; Cattle; Birth, weaning, and yearling weight, calving ease, carcass weight, average daily gain, dry matter intake, backfat thickness, ribeye area, hip height

20_04

8.218

−4.810

0.438

12

SH3PXD2B

Intron

[24, 40, 61]; Cattle, human; Birth and weaning weights, carcass weight, fat thickness, calving ease, average daily gain, development of eyes, heart, and bone

14_24

6.670

6.144

0.099

31

PENK, LOC112449660

Intergenic

[20, 24, 26, 29, 31, 46, 74]; Cattle, rat; Birth, weaning, and yearling weights, calving ease, carcass weight, milk and protein yield, stillbirth, body size, mid-test metabolic weight, bone development

6_40

5.810

6.922

0.060

5

SLIT2

Intron

[20, 24, 40, 42, 59, 60]; Cattle, mouse; Birth, weaning, and yearling weight, calving ease, average daily gain, carcass weight, hip height, milk fat and protein, development of central nervous system

7_90

5.781

−5.278

0.097

5

MIR3660, CETN3

Intergenic

[42, 49, 75,76,77]; Cattle, human, mice; Birth and yearling weights, conception rate, cell proliferation control, insulin response, cell regulation, centriole duplication and mitosis in embryonic development

6_32

5.366

4.287

0.277

26

GRID2

Intron

[40, 42, 46, 64]; Human, cattle; Mammalian nervous system mediation, dry matter intake, average daily gain, birth weight, milk fat yield

  1. a Chromosome_Megabase
  2. b Minor Allele Frequency
  3. c Single Nucleotide Polymorphisms