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Table 6 Summary of GxE interactions detected for weaning weight in U.S. Red Angus cattle

From: Genome-wide association and genotype by environment interactions for growth traits in U.S. Red Angus cattle

Chr_Mba

-log10 P-value

Regression Beta

MAFb

Supporting SNPsc

Positional Candidate Genes

Lead SNP Location

Scientific Precedence [reference]; organism; trait

7_101d

6.537

19.526

0.216

14

LOC112447568, TRNAE-UUC

Intergenic

[46, 47, 49, 81, 88, 89]; Cattle, yeast; Milk fatty acid, stature, milk fat yield, and conception rate, protein homeostasis and heat stress adaptation

28_24e

6.213

−6.627

0.404

5

DNAJC12, SIRT1

Intergenic

[46,47,48, 81, 83, 84, 90,91,92,93]; Cattle, human; Milk fatty acids, milk fat and protein yield, milk fat and protein percentage, body measurements and meat quality, stature, birth weight, calving ease, maturity rate, cell proliferation, senescence in response to cellular stress

7_99d

5.746

15.175

0.296

5

LOC112447496, LOC112447497

Intergenic

[46, 49, 88, 94, 95]; Cattle; Shear force, milk fat yield, and conception rate associations

11_69f

5.550

118.159

0.051

7

LCLAT1

Intron

[11, 40, 83, 96,97,98]; Mouse, cattle; Mitochondrial structure and function, fatty acid oxidation, energy metabolism, obesity and diabetes association, metabolic body weight, milk fatty acid and protein composition, fatty acid associations

6_88d

5.532

42.188

0.014

5

LOC112447164, COX18

Intergenic

[46, 49, 84, 99,100,101,102,103,104,105]; Cattle, human; Milk, and protein yield, conception rate, mitochondrial biogenesis, oxygen consumption process regulated to adapt to changing environmental conditions

5_78f

5.509

−117.747

0.031

7

LOC782092

3’UTR

[62, 106,107,108,109]; Cattle; Tenderness association, pregnancy rate, stayability, milk fatty acid

  1. a Chromosome_Megabase
  2. b Minor Allele Frequency
  3. c Single Nucleotide Polymorphisms
  4. d Significant for U.S. Desert Ecoregion
  5. e Significant for U.S. Upper Midwest & Northeast Ecoregion
  6. f Significant for U.S. Foothills Ecoregion