Fig. 6

a. Overrepresented neighboring gene functions in the sIG pairs. sIG pairs were classified as overrepresented (or underrepresented) if the observed number was 10% greater than the expected value (See Materials and methods). Graphs display the overrepresented gene functions with observed proportions greater than 5% and more than 50 IG couples. The blue (red) bar is the observed (expected) proportions under a random distribution. b. A typical example of IS5 – ‘DNA-binding response regulator’ sIG pair and its genetic context. For each IG couple, the first line displays the ISs (rectangles) and the genes (arrows), while the second line shows the predicted (in gray) or experimentally known (in gold) regulatory motifs, including TFBSs, promoters and transcription terminators. Blue genes and the yellow IS family (here IS5) are involved in the syntenic IG (sIG) pair. For each IG couple, the genome name, phylum name, NCBI accession number, and coordinates of the genetic environment as well as the IS name and gene name of the IS-Gene participating in the sIG pair are shown