Fig. 4

Confidence intervals of estimates from linear mixed model coupled with contrast matrix for historical data with a “partly dropped” change points. Figure a) shows the increasing points in time (x-axis) of the sampled historical data in association with gene expression (y-axis) with two expected change points. Each color is related to one mother mouse. Subfigures b), c) and d) show the estimates (x-axis) including confidence intervals for the observed contrasts (y-axis) with methods Changepoint, Sequen and McDermott, respectively. The blue line indicates the simulated effect