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Table 3 Significant DEGs from the comparison between low and high host resistance steers at different timepoints

From: Transcriptional changes in the peripheral blood leukocytes from Brangus cattle before and after tick challenge with Rhipicephalus australis

Time pointa

Symbol

Entrez ID

Name

Log2FCb

p-val

FDRc

T0

BOLA-DQA2

282,535

major histocompatibility complex, class II, DQ alpha 2

6.66

3.2E-12

2.3E-08

BOLA-DQA5

282,494

major histocompatibility complex, class II, DQ alpha 5

2.78

7.3E-05

2.4E-02

LOC101902385

101,902,385

uncharacterized LOC101902385

2.22

9.2E-08

1.1E-04

LOC510904

510,904

uncharacterized LOC510904

1.69

1.8E-04

4.2E-02

DNAH9

790,891

dynein axonemal heavy chain 9

1.58

2.3E-04

4.8E-02

KLK1

493,738

kallikrein 1

1.32

8.5E-06

5.3E-03

LOC783893

783,893

ankyrin repeat domain-containing protein 26-like

1.26

2.3E-04

4.8E-02

LOC100848077

100,848,077

zinc finger protein 665-like

1.14

1.9E-05

9.2E-03

LOC101908204

101,908,204

uncharacterized LOC101908204

1.09

1.6E-04

4.0E-02

FGD5

539,766

FYVE, RhoGEF and PH domain containing 5

1.08

6.9E-05

2.4E-02

ARHGAP23

523,030

Rho GTPase activating protein 23

−1.01

7.4E-07

2.0E-07

WC1.3

514,534

WC1.3 molecule

−1.01

1.8E-05

2.5E-02

LOC100139325

100,139,325

zinc finger protein 585A

−1.02

1.0E-07

9.4E-04

DNAH14

516,576

dynein axonemal heavy chain 14

−1.02

1.5E-04

1.5E-02

LAMA4

529,670

laminin subunit alpha 4

−1.04

2.1E-10

3.5E-02

DCLK1

613,449

doublecortin like kinase 1

−1.12

4.1E-14

1.5E-02

KANK1

534,869

KN motif and ankyrin repeat domains 1

−1.16

1.3E-05

4.3E-06

SMAD9

540,806

SMAD family member 9

−1.16

2.1E-04

9.2E-06

LOC101906508

101,906,508

uncharacterized LOC101906508

−1.17

1.6E-07

2.4E-02

TMIGD3

104,564,307

transmembrane and immunoglobulin domain containing 3

−1.21

1.9E-07

5.0E-05

COL26A1

617,340

collagen type XXVI alpha 1 chain

−1.86

8.0E-05

4.1E-03

T3

TTLL1

539,530

tubulin tyrosine ligase like 1

1.16

6.9E-06

1.9E-02

OSBP2

510,311

oxysterol binding protein 2

1.11

1.7E-05

2.9E-02

LOC524810

524,810

IgM

0.90

3.0E-06

1.0E-02

RRM2

508,167

ribonucleotide reductase regulatory subunit M2

0.41

1.7E-05

2.9E-02

BLA-DQB

539,241

MHC class II antigen

−0.67

1.2E-06

5.5E-03

LOC506989

506,989

mitochondrial ribosomal protein L17-like

−0.82

1.2E-05

2.7E-02

FBN1

281,154

fibrillin 1

−1.36

2.0E-11

2.7E-07

C26H6orf52

112,444,525

chromosome 26 C6orf52 homolog

−1.56

9.3E-11

6.4E-07

T12

LOC112446120

112,446,120

small nucleolar RNA U2–19

2.60

9.8E-06

3.5E-02

BOLA-DRB2

538,700

histocompatibility complex, class II, DR beta 2

−1.15

1.5E-06

9.4E-03

LRRC32

615,467

leucine rich repeat containing 32

−1.49

2.0E-06

9.4E-03

LOC104974401

104,974,401

uncharacterized LOC104974401

−1.55

1.2E-12

1.7E-08

  1. a Timepoint observed during tick infestation trial with R. australis larvae. T0 = tick-naïve (pre-infestation); T3 = 3 weeks post-initial infestation; T12 = 12 weeks post-initial infestation
  2. b log2FC represents the fold change in gene expression between low (LR) and high (HR) host resistance steers at a specified timepoint
  3. c FDR represents the false discovery rate (Benjamini-Hochberg multiple test correction of the p-value). Table displays genes below threshold FDR < 0.05