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Table 1 UL4015-23 peptides found in CMV strains from 199 patients and HLA-E predicted binders:

From: HLA-E restricted cytomegalovirus UL40 peptide polymorphism may represent a risk factor following congenital infection

9-mer UL4015-23

(accession number)

(n) % patients

% OPT

Cleavage model

predicteda

Binding Scoreb

LMAPRTLLL (9)

(1) 0.5

97.54

Yes

277.0

VIAPRTLIL (17)

(1) 0.5

90.85

yes

258.0

VLAPRTLLL (7)

(1) 0.5

95.42

yes

271.0

VMAPRILIL (4)

(2) 1

80.99

yes

230.0

VMAPRILVL (11)

(4) 2

80.28

yes

228.0

VMAPRSLIL (15)

(1) 0.5

87.68

yes

249.0

VMAPRSLLL (6)

(2) 1

89.44

yes

254.0

VMAPRTLFL(12)

(2) 1

91.90

yes

261.0

VMAPRTLIL (3)

(120) 60.3

98.24

yes

279.0

VMAPRTLIM (5)

(1) 0.5

94.01

No

267.0

VMAPRTLIV (18)

(1) 0.5

95.77

yes

272.0

VMAPRTLLL (1)

(20) 10

100

yes

284.0

VMAPRTLVL (2)

(36) 18

97.54

yes

277.0

VMDPRTLIL (13)

(1) 0.5

88.03

yes

250.0

VMGPRTLLL (14)

(1) 0.5

91.55

yes

260.0

VMTPRTLIL (19)

(1) 0.5

90.85

yes

258.0

VMTPRTLLL(10)

(1) 0.5

92.61

yes

263.0

VMTPRTLVL (8)

(2) 1

90.14

yes

256.0

VMVPRTLVL (16)

(1) 0.5

88.03

yes

250.0

  1. % OPT is the percentile score of the predicted peptide relative to that of the consensus. The consensus is the sequence that yields the maximum score, namely optimal score (OPT) with the selected profile. aProteasomal cleavage predictions was carried out using three optional models obtained applying statistical language models to a set of knwon epitopes restricted by human MHCI molecules. * The binding potential (score) of any peptide sequence (query) to a given MHCI is obtained by aligning the relevant PSSM with the protein segments, and adding up the profile scores that match the residue type and position in the profile. bBinding Score according to maximum score of 284 obtained with VMAPRTLLL. GenBank accession numbers: (1) OM397419, (2) OM397420, (3) OM397421, (4) OM397422, (5) OM397423, (6) OM397424, (7) OM397425, (8) OM397426, (9) OM397427, (10) OM397428, (11) OM397429, (12) OM397430, (13) OM397431, (14) OM397432, (15) OM397433, (16) OM397434, (17) OM397435, (18) OM397436, (19) OM397437.