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Table 1 UL4015-23 peptides found in CMV strains from 199 patients and HLA-E predicted binders:

From: HLA-E restricted cytomegalovirus UL40 peptide polymorphism may represent a risk factor following congenital infection

9-mer UL4015-23
(accession number)
(n) % patients % OPT Cleavage model
predicteda
Binding Scoreb
LMAPRTLLL (9) (1) 0.5 97.54 Yes 277.0
VIAPRTLIL (17) (1) 0.5 90.85 yes 258.0
VLAPRTLLL (7) (1) 0.5 95.42 yes 271.0
VMAPRILIL (4) (2) 1 80.99 yes 230.0
VMAPRILVL (11) (4) 2 80.28 yes 228.0
VMAPRSLIL (15) (1) 0.5 87.68 yes 249.0
VMAPRSLLL (6) (2) 1 89.44 yes 254.0
VMAPRTLFL(12) (2) 1 91.90 yes 261.0
VMAPRTLIL (3) (120) 60.3 98.24 yes 279.0
VMAPRTLIM (5) (1) 0.5 94.01 No 267.0
VMAPRTLIV (18) (1) 0.5 95.77 yes 272.0
VMAPRTLLL (1) (20) 10 100 yes 284.0
VMAPRTLVL (2) (36) 18 97.54 yes 277.0
VMDPRTLIL (13) (1) 0.5 88.03 yes 250.0
VMGPRTLLL (14) (1) 0.5 91.55 yes 260.0
VMTPRTLIL (19) (1) 0.5 90.85 yes 258.0
VMTPRTLLL(10) (1) 0.5 92.61 yes 263.0
VMTPRTLVL (8) (2) 1 90.14 yes 256.0
VMVPRTLVL (16) (1) 0.5 88.03 yes 250.0
  1. % OPT is the percentile score of the predicted peptide relative to that of the consensus. The consensus is the sequence that yields the maximum score, namely optimal score (OPT) with the selected profile. aProteasomal cleavage predictions was carried out using three optional models obtained applying statistical language models to a set of knwon epitopes restricted by human MHCI molecules. * The binding potential (score) of any peptide sequence (query) to a given MHCI is obtained by aligning the relevant PSSM with the protein segments, and adding up the profile scores that match the residue type and position in the profile. bBinding Score according to maximum score of 284 obtained with VMAPRTLLL. GenBank accession numbers: (1) OM397419, (2) OM397420, (3) OM397421, (4) OM397422, (5) OM397423, (6) OM397424, (7) OM397425, (8) OM397426, (9) OM397427, (10) OM397428, (11) OM397429, (12) OM397430, (13) OM397431, (14) OM397432, (15) OM397433, (16) OM397434, (17) OM397435, (18) OM397436, (19) OM397437.