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Table 1 Optimised F1 scores in A. thaliana (Cvi-0). In comparison to the reference SNPs obtained from 1001 genomes consortium data, scores are derived when using real WGS and WGBS data, alongside in silico WGBS data derived from the WGS reads and alignments, respectively

From: Manipulating base quality scores enables variant calling from bisulfite sequencing alignments using conventional bayesian approaches

 

Real data

in silico

 

WGS

WGBS

reads

alignments

GATK3.8

0.9189

0.8177

0.8508

0.9069

Freebayes

0.8247

0.7670

0.8039

0.8247

Platypus (default)

0.7423

0.7026

0.7709

0.7935

Platypus (assembly)

0.6378

0.5980

0.6449

0.6509