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Table 1 Nucleotide diversity (π) and Tajima’s D values around the key resistance-related proteins’ region in PEc, PEz and PEa populations

From: Equus roundworms (Parascaris univalens) are undergoing rapid divergence while genes involved in metabolic as well as anthelminic resistance are under positive selection

Scaffold ID

Start

End

Descriptiona

Ï€

Tajima’D

Significantly selected populations

PEcb

PEzc

PEad

PEcb

PEzc

PEad

PgR045

1,372,050

1,381,671

β tubulin

0.0017

0.0019

0.0005

1.4698

2.5324

1.268

PEc, PEz, PEa

PgR004

1,320,231

1,320,527

glc-1

0.0021

0.0017

0.0007

-0.4035

2.0857

-1.8797

PEa

PgB04

2,029,204

2,057,834

pgp-1

0.0099

0.0095

0.008

1.5276

1.3328

0.0662

-

PgR063X

121,395

124,033

pgp-3

0.0002

0.0007

0.0002

0.3278

-0.0274

-1.8733

PEa

PgB05

571,021

589,065

mrp-7

0.0119

0.0089

0.0097

-0.2053

1.2363

0.4773

-

PgR035X

1,170,116

1,202,939

mrp-6

0.0051

0.0021

0.0047

2.0705

0.7746

0.6784

-

PgB09

815,741

828,043

mrp-5

0.0053

0.0037

0.002

0.1012

0.6472

-0.6395

-

PgB10

552,422

565,520

mrp-4

0.0093

0.0099

0.0092

0.9641

1.3762

1.5909

-

PgB03

2,066,848

2,079,134

haf-2

0.0033

0.0036

0.0047

0.783

1.4183

0.811

-

PgR004

2,938,177

2,953,151

haf-5

0.0232

0.02

0.0173

0.7172

1.6294

-0.3418

-

PgR006

879,399

911,228

cup-4

0.0083

0.0079

0.0075

2.0797

2.1662

0.6134

-

PgR009X

834,742

840,950

bre-4

0.0064

0.002

0.0004

1.2283

1.3452

0.7223

-

PgR004

1,575,226

1,593,120

unc-29

0.0031

0.0046

0.0036

0.1117

1.9462

1.3307

-

PgB12X

400,372

407,591

unc-38

0.0003

0.0001

0.0004

-1.4946

0.0306

-0.2792

PEc

PgR024

1,427,386

1,436,555

Glycosyl hydrolase 18

0.0049

0.0074

0.002

-0.7514

0.6444

0.2132

-

PgR003

3,165,465

3,176,989

nrf-6

0.0052

0.0051

0.0034

2.4611

3.49

2.2507

-

PgR008

3,213,688

3,247,697

ced-7

0.0082

0.0067

0.0064

0.5927

0.2795

0.3853

-

PgR001X

1,705,437

1,736,423

aex-3

0.0018

0.0005

0.0011

0.2075

2.0238

-0.1421

-

PgB07

1,545,397

1,551,068

CYP_2B19

0.0013

0.0003

0.0018

1.0607

1.0553

0.9086

-

PgR002

512,210

524,078

CYP_13A8

0.0002

0.0014

0.0051

-0.1263

1.1847

0.6614

-

PgR010

2,986,365

2,996,675

CYP_3A31

0.0072

0.0086

0.0065

1.3057

2.4035

2.0071

-

PgR020

456,556

464,491

CYP_2C8

0.0068

0.0081

0.0091

0.7683

1.0655

0.6074

-

PgR027

284,432

291,992

CYP_2C25

0.0036

0.0043

0.0035

0.3752

1.6727

-0.4168

-

PgR033

836,482

846,733

CYP_4C1

0.0015

0.0107

0.0097

-2.6423

2.4022

1.5867

PEc

PgR049

713,990

725,852

CYP_4V2

0.0001

0.0005

0.0008

-1.4324

0.347

0.639

PEc

PgR012

2,339,498

2,343,997

CYP_3A7

0.0063

0.0125

0.0094

-1.2345

1.6788

0.0835

PEc

  1. anote: β tubulin, β tubulin; glc-1, glutamate-gated chloride channel alpha; pgp, multidrug resistance-associated protein family; mrp, multidrug resistance protein family; haf, half transporter family; cup-4, acetylcholine receptor-like protein; bre-4, beta-n-acetylgalactosaminyltransferase bre-4; unc, Acetylcholine receptor family; nrf-6, Nose resistant to fluoxetine protein 6; ced-7, ABC transporter ced-7; aex-3, MAP kinase-activating death domain protein; CYP, cytochrome P450 family
  2. bPEc, P. univalens from Equus caballus
  3. cPEz, P. univalens from Equus zebra
  4. dPEa, P. univalens from Equus asinus
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BMC Genomics

ISSN: 1471-2164

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