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Table 1 Epidemiological characteristics of the sample

From: Whole genome sequencing analysis to evaluate the influence of T2DM on polymorphisms associated with drug resistance in M. tuberculosis

 

T2DM isolatesa

TB isolatesb

Total

(n = 74)

(n = 74)

(n = 148)

Sex

 Male

44(59%)

40 (54%)

84(57.4%)

 Female

30 (41%)

34 (45%)

64(42.6%)

Age

Mean (± SD)

50 (± 10)

42 (± 15)

47 (± 13)

Country

 Georgia

8 (10.8%)

28 (37%)

36 (24.3%)

 Mexico

23 (31%)

11 (14.8%)

34 (23%)

 Moldova

6 (8.1%)

14 (18.9%)

20 (13.5%)

 Belarus

4 (5.4%)

11 (14.8%)

15 (10.1%

 Romania

2 (2.7%)

10 (13.5%)

12 (8.1%)

 Peru

11 (14.8%)

0 (0.0%)

11 (7.4%)

 Indonesia

9 (12.1%)

0 (0.0%)

9 (6.1%)

 Spain

8 (10.8%)

0 (0.0%)

8 (5.4%)

 Azerbaijan

3 (4%)

0 (0.0%)

3 (2%)

Resistance typec

 MR

20 (27%)

20 (27%)

40 (27%)

 POL

9 (12.1%)

9 (12.1%)

18 (12.1%)

 MDR

31 (48.8%)

31 (48.8%)

62 (41.8%)

 XDR

14 (18.9%)

14 (18.9%)

28 (18.9%)

Drug-resistance

 Isoniazid

58 (67.5%)

55 (74.3%)

113 (76.3%)

 Rifampicin

50 (67.5%)

53 (71.6%)

103 (69.5%)

 Streptomycin

21 (28.3%)

42 (56.7%)

63 (42.5%)

 Ethambutol

27 (36.4%)

37 (50%)

64 (43.2%)

 Pyrazinamide

27 (36.4%)

24 (32.4%)

51 (34.4%)

 Amikacin

19 (25.6%)

30 (40.5%)

49 (33.1%)

 Fluoroquinolones

16 (21.6%)

17 (22.9%)

33 (22.3%)

  1. aT2DM: Host with diabetes mellitus type 2 and tuberculosis. bTB Isolates: Host without diabetes mellitus type 2 and tuberculosis. cMR: mono-resistant tuberculosis, POL poly-resistant tuberculosis, MDR multidrug-resistant tuberculosis, XDR extensively drug resistant tuberculosis