Name | Role in the Pathway | BLAST | Exonerate | Conserved domains | References |
---|---|---|---|---|---|
Delta/Serrate (Jagged) | Ligand of the Notch receptor | Yes | Yes | Yes | |
Notch | Receptor | Yes | Yes | No | |
RBP-J | Transcription factor activated by Notch | Yes | Yes | No | |
Mastermind | Co-activator of RBP-J | Yes | Yes | No | |
p300 | Co-activator of RBP-J | Yes | Yes | No | |
NACK | Co-activator of RBP-J | Yes | No | No | |
CIR1 | Co-repressor of RBP-J | Yes | Yes | No | |
NCoR | Co-repressor of RBP-J | Yes | Yes | Yes | [111] |
HDAC1 | Co-repressor of RBP-J | Yes | Yes | Yes | [112] |
MINT | Co-repressor of RBP-J | Yes | Yes | Yes | [111] |
Fringe | Post-translational maturation of Notch | Yes | Yes | No | |
POFUT1 | Post-translational maturation of Notch | Yes | Yes | Yes | [113] |
Poglut | Post-translational maturation of Notch | Yes | Yes | Yes | [114] |
Furin | Receptor proteolysis | Yes | Yes | Yes | [115] |
Neuralized | Ubiquitination of Jagged | Yes | Yes | Yes | |
Mindbomb | Ubiuitination of Delta | Yes | Yes | Yes | [117] |
Nicastrin | Receptor proteolysis | Yes | Yes | Yes | |
Presenilin 1 | Receptor proteolysis | Yes | No | No | |
ADAM 10/17 | Metalloprotease | Yes | Yes | No | [21] |
HES | Canonical target gene | Yes | Yes | Yes | |
HEY1 | Canonical target gene | Yes | Yes | Yes | |
Numb | Negative regulator of the Notch pathway | Yes | Yes | No | [118] |
LNX2 | Negative regulator of Numb | Yes | Yes | Yes | [121] |
ACBD3 | Activator of Numb | Yes | Yes | Yes | |
NAK | Positive regulator of the Notch pathway | Yes | Yes | No | [118] |
Mesp2 | Activates Fringe, induces degradation of Mastermind | Yes | No | Yes | [107] |
Nedd4 | Targets Notch and Deltex for degradation | Yes | Yes | Yes | [123] |
Notchless | Context-dependent positive or negative regulator | Yes | Yes | Yes | [36] |
Deltex | Context-dependent positive or negative regulator. Antagonizes Nedd4 | Yes | Yes | Yes |