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Table 5 Select components of the Notch signaling pathway identified in the draft genome of O. brevispinum using reference sequences from UniProt and Echinobase. For each gene, we list its name, the known function in the pathway, and whether or not the gene was recovered from the draft genome with independent BLAST and exonerate alignments. In addition, we also indicate if we could identify conserved protein domains in the predicted protein sequences

From: Twinkle twinkle brittle star: the draft genome of Ophioderma brevispinum (Echinodermata: Ophiuroidea) as a resource for regeneration research

Name Role in the Pathway BLAST Exonerate Conserved domains References
Delta/Serrate (Jagged) Ligand of the Notch receptor Yes Yes Yes [21, 35]
Notch Receptor Yes Yes No [21, 107]
RBP-J Transcription factor activated by Notch Yes Yes No [21, 35]
Mastermind Co-activator of RBP-J Yes Yes No [21, 35, 107]
p300 Co-activator of RBP-J Yes Yes No [108, 109]
NACK Co-activator of RBP-J Yes No No [108, 110]
CIR1 Co-repressor of RBP-J Yes Yes No [21, 35]
NCoR Co-repressor of RBP-J Yes Yes Yes [111]
HDAC1 Co-repressor of RBP-J Yes Yes Yes [112]
MINT Co-repressor of RBP-J Yes Yes Yes [111]
Fringe Post-translational maturation of Notch Yes Yes No [21, 35]
POFUT1 Post-translational maturation of Notch Yes Yes Yes [113]
Poglut Post-translational maturation of Notch Yes Yes Yes [114]
Furin Receptor proteolysis Yes Yes Yes [115]
Neuralized Ubiquitination of Jagged Yes Yes Yes [3, 116]
Mindbomb Ubiuitination of Delta Yes Yes Yes [117]
Nicastrin Receptor proteolysis Yes Yes Yes [21, 118]
Presenilin 1 Receptor proteolysis Yes No No [21, 118]
ADAM 10/17 Metalloprotease Yes Yes No [21]
HES Canonical target gene Yes Yes Yes [118120]
HEY1 Canonical target gene Yes Yes Yes [118120]
Numb Negative regulator of the Notch pathway Yes Yes No [118]
LNX2 Negative regulator of Numb Yes Yes Yes [121]
ACBD3 Activator of Numb Yes Yes Yes [118, 122]
NAK Positive regulator of the Notch pathway Yes Yes No [118]
Mesp2 Activates Fringe, induces degradation of Mastermind Yes No Yes [107]
Nedd4 Targets Notch and Deltex for degradation Yes Yes Yes [123]
Notchless Context-dependent positive or negative regulator Yes Yes Yes [36]
Deltex Context-dependent positive or negative regulator. Antagonizes Nedd4 Yes Yes Yes [112, 123]