Table 3 Differentially expressed cytokines and their receptors. TND = transcript not detected
Gene group | Gene | Description | Differential expression in High dose | Differential expression in medium dose | Differential expression in Low dose | |||
|---|---|---|---|---|---|---|---|---|
Log2 Fold change | Adjusted p-value | Log2 Fold change | Adjusted p-value | Log2 Fold change | Adjusted p-value | |||
Cytokines | IL6 | Interleukin 6 | 5.67 | 1.50E-26 | 4.01 | 4.76E-11 | TND | TND |
IL17B | Interleukin 17B | 1.56 | 2.94E-02 | TND | TND | TND | TND | |
IL16 | Interleukin 16 | TND | TND | −2.08 | 4.17E-03 | TND | TND | |
IL27 | Interleukin 27 | 2.20 | 4.28E-03 | 2.61 | 2.87E-03 | TND | TND | |
IFN-ω | Interferon omega 6 | −1.62 | 3.22E-02 | TND | TND | TND | TND | |
TNFSF12 | TNF superfamily member 12 | 1.53 | 1.01E-04 | 1.66 | 6.77E-05 | TND | TND | |
TNFSF13 | TNF superfamily member 13 | TND | TND | 1.63 | 3.63E-03 | TND | TND | |
HBEGF | Heparin binding EGF like growth factor | 1.83 | 4.07E-03 | 1.76 | 9.45E-03 | TND | TND | |
VEGFA | Vascular endothelial growth factor A | 3.81 | 1.66E-13 | 2.83 | 1.12E-06 | TND | TND | |
Cytokine receptor families | IL1RL1 | Interleukin 1 receptor like 1 | 5.00 | 1.11E-09 | 4.62 | 2.58E-07 | TND | TND |
IL10RA | Interleukin 10 receptor subunit alpha | −1.32 | 1.64E-03 | −2.27 | 1.49E-06 | TND | TND | |
IL15RA | interleukin 15 receptor subunit alpha | 1.54 | 4.86E-02 | TND | TND | TND | TND | |
IL17RE | Interleukin 17 receptor E like | 1.64 | 2.14E-02 | TND | TND | TND | TND | |
IL21R | Interleukin 21 receptor | −2.61 | 1.44E-06 | −2.78 | 3.62E-05 | TND | TND | |
IL27RA | Interleukin 27 receptor subunit alpha | TND | TND | −1.48 | 4.36E-03 | TND | TND | |
IL31RA | Interleukin 31 receptor A | −2.31 | 3.59E-03 | − 2.75 | 5.42E-03 | TND | TND | |
TNFRSF11A | TNF receptor superfamily member 11a | −2.67 | 5.45E-04 | −2.05 | 1.24E-02 | TND | TND | |
TRAF7 | TNF receptor associated factor 7 | 1.59 | 4.75E-05 | TND | TND | TND | TND | |
TNFRSF13B | TNF receptor superfamily member 13B | 2.34 | 8.13E-07 | TND | TND | TND | TND | |
TNFRSF18 | TNF receptor superfamily member 18 | 1.99 | 3.68E-03 | TND | TND | TND | TND | |
TNFRSF9 | TNF receptor superfamily member 9 | −1.70 | 3.90E-02 | −3.16 | 9.69E-03 | TND | TND | |
TNFRSF21 | TNF receptor superfamily member 21 | −1.92 | 1.19E-03 | −1.42 | 2.09E-02 | TND | TND | |
TNFRSF13C | TNF receptor superfamily member 13C | TND | TND | −2.33 | 7.88E-03 | TND | TND | |
IRAK1 | Interleukin 1 receptor associated kinase 1 | 1.73 | 2.26E-06 | TND | TND | TND | TND | |
IRAK3 | Interleukin 1 receptor associated kinase 3 | −0.87 | 3.75E-02 | TND | TND | TND | TND | |
IRAK4 | Interleukin 1 receptor associated kinase 4 | −1.22 | 1.67E-02 | TND | TND | TND | TND | |