Fig. 5

Immune cell differentially methylated region (cDMRs) harbor immune capacity GWAS SNPs. A Enrichment barplot of GWAS SNPs for various trait classes among cDMRs. Dashed line indicates threshold for significance. B CD8B/CD8A locus methylation plot including a CD8⁺ T cell LMR overlapping a CD8⁺ T cell %/CD8⁻ T cell % GWAS SNP (red asterisk). Gray boxes indicate cDMRs, and black dots indicate CpG coordinates. C Normalized CD8A abundance in porcine peripheral blood mononuclear cells by CD8B SNP genotype. CC: N = 12, CT: N = 12, TT: N = 14. D Normalized NDRG1 abundance by NDRG1 SNP genotype. CC: N = 13, CT: N = 12, TT: N = 10. Different letters indicate statistically significant differences (FDR < 0.05)