Table 3 Frequency of drug resistance mutations, N = 24
Drug | Gene | Mutation | Resistant (n/N (%)) | Classification of the mutation | Resistance level |
|---|---|---|---|---|---|
Isoniazid | fabG1 | c.-15C > T | 1/24 (4.2) | Common | High |
| Â | fabG1 | CTG607CTA | 1/24 (4.2) | Common | Low |
|  | fabG1 | c.-8 T > A | 1/24 (4.2) | Common | Low |
| Â | inhA | Ser94Ala | 1/24 (4.2) | Common | Low |
| Â | katG | Ser315Thr | 9/24 (37.5) | Common | High |
Rifampicin | rpoB | Gln432Glu | 3/24 (12.5) | Common | High |
| Â | rpoB | His445Asn | 1/24 (4.2) | Rare | Low |
| Â | rpoB | Leu430Pro | 1/24 (4.2) | Common | High |
| Â | rpoB | Ser441Gln | 2/24 (8.3) | Rare | Low |
| Â | rpoB | Ser450Leu | 3/24 (12.5) | Common | High |
Ethambutol | embB | Asp1024Asn | 1/24 (4.2) | Common | High |
| Â | embB | Gln497Arg | 2/24 (8.4) | Common | High |
| Â | embB | Leu359Ile | 1/24 (4.2) | Common | High |
| Â | embB | Met306Ile | 4/24 (16.7) | Common | High |
Pyrazinamide | pncA | Ala30Val | 2/24 (8.4) | Common | High |
| Â | pncA | E111$ | 1/24 (4.2) | Common | Low |
| Â | pncA | GAG331TAG | 2/24 (8.4) | Common | High |
| Â | pncA | Leu172Pro | 1/24 (4.2) | Common | High |
| Â | pncA | Phe106Leu | 1/24 (4.2) | Rare | Low |
| Â | pncA | Thr160Ala | 1/24 (4.2) | Common | High |
Streptomycin | gid | Pro93Leu | 1/24 (4.2) | - | Â |
| Â | rpsL | Lys88Met | 4/24 (16.7) | - | Â |
| Â | rrs | Ser172Cys | 1/24 (4.2) | - | Â |
Ethionamide | fabG | c.-15C > T | 1/24 (4.2) | - |  |
| Â | inhA | Ser94Ala | 1/24 (4.2) | - | Â |
Fluoroquinolones | gyrA | Ala90Val | 1/24 (4.2) | Common (LEV, MOX CC) | Â |
| Â | gyrA | Asp94Gly | 1/24 (4.2) | Common | Â |