Genomic characteristics of two most widely used BCG vaccine strains: Danish 1331 and Pasteur 1173P2

Asadian, Mahla; Hassanzadeh, Seyed Mehdi; Safarchi, Azadeh; Douraghi, Masoumeh

doi:10.1186/s12864-022-08826-9

BMC Genomics

Table 2 M. tuberculosis antigens containing variants in non-epitope sequences in two BCG strains

From: Genomic characteristics of two most widely used BCG vaccine strains: Danish 1331 and Pasteur 1173P2

Epitope ID	H37Rv locus tag	Gene name	Product	Genetic variation	Pasteur 1173P2	Danish 1331
2190	Rv0171	mce1C	Mce family protein Mce1C	nSNP^a	+	+
4002	Rv3018c	PPE46	PPE family protein PPE46	nSNP	+	-
4520	Rv2627c	-	Hypothetical protein	nSNP	+	+
9474	Rv2608	PPE42	PPE family protein PPE42	nSNP	+	+
18,059	Rv1291c	-	Hypothetical protein	sSNP^b	+	+
24,566	Rv1037c	esxI	ESAT-6 like protein EsxI	nSNP	+	-
32,710	Rv3467	-	Hypothetical protein	nSNPs	+	+
32,860	Rv0670	end	Endonuclease IV	sSNP	+	+
39,011	Rv3804c	fbpA	Diacylglycerol acyltransferase/mycolyltransferase Ag85A	sSNP	+	+
45,757	Rv0170	mce1B	Mce family protein Mce1B	nSNP	+	+
55,156	Rv1945	-	Hypothetical protein	sSNPs & nSNPs	+	+
55,188	Rv1641	infC	Initiation factor IF-3	nSNP	+	+
55,191	Rv3689	-	Transmembrane protein	nSNP	+	+
55,192	Rv3378c	-	Diterpene synthase	sSNP & nSNP	+	+
55,315	Rv2823c	-	CRISPR-associated protein Cas10/Csm1	Insertion	+	+
55,334	Rv2476c	gdh	NAD-dependent glutamate dehydrogenase	nSNP & Deletion	+	+
57,680	Rv0174	mce1F	Mce family protein Mce1F	sSNPs	+	+
60,095	Rv3714c	-	Hypothetical protein	sSNP	+	+
64,663	Rv0169	mce1A	Mce family protein Mce1A	nSNPs	+	+
92,817	Rv1886c	fbpB	Diacylglycerol acyltransferase/mycolyltransferase Ag85B	nSNP	+	+
93,270	Rv3839	-	Hypothetical protein	nSNP	+	+
99,857	Rv2770c	PPE44	PPE family protein PPE44	sSNP & nSNP	+	+
99,866	Rv2770c	PPE44	PPE family protein PPE44	sSNP & nSNP	+	-
118,590	Rv2600	-	Integral membrane protein	Deletion	+	+
120,392	Rv1866	-	Hypothetical protein	sSNP & nSNP	+	+
120,408	Rv3883c	mycP1	Membrane-anchored mycosin	sSNP & nSNP	+	+
120,481	Rv0934	pstS1	Phosphate ABC transporter substrate-binding lipoprotein PstS	nSNP	+	+
120,887	Rv3736	-	AraC/XylS family transcriptional regulator	sSNP & nSNP	+	+
121,059	Rv0755c	PPE12	PPE family protein PPE12	sSNP & nSNP	+	+
125,165	Rv1361c	PPE19	PPE family protein PPE19	sSNPs & nSNP	+	+
126,028	Rv3296	lhr	ATP-dependent helicase	nSNPs	+	+
126,912	Rv0024	-	NLP/P60 family protein	Deletion	+	+
140,543	Rv2006	otsB1	Trehalose-6-phosphate phosphatase OtsB	sSNPs & nSNP	+	+
140,561	Rv1997	ctpF	Cation transporter ATPase F	sSNP & nSNP	+	+
140,576	Rv2780	ald	L-alanine dehydrogenase	Deletion	+	+
140,597	Rv3499c	mce4A	Mce family protein Mce4A	sSNP	+	-
140,615	Rv2531c	adi	Amino acid decarboxylase	sSNP	+	+
140,617	Rv2813	-	Hypothetical protein	nSNP	+	+
144,870	Rv1769	-	Hypothetical protein	sSNP	-	+
161,402	Rv0787	-	Hypothetical protein	nSNP	+	+
168,735	Rv1789	PPE26	PPE family protein PPE26	sSNP	+	+
196,087	Rv3343c	PPE54	PPE family protein PPE54	sSNPs & nSNPs	+	+
229,047	Rv1009	rpfB	Resuscitation-promoting factor RpfB	nSNPs	+	+
738,104	Rv3616c	espA	ESX-1 secretion-associated protein EspA	nSNPs	+	+
851,000	Rv1626	-	Two-component system transcriptional regulator	sSNP	+	+
857,468	Rv3792	aftA	Arabinofuranosyltransferase	sSNP	+	+
1,081,150	Rv0442c	PPE10	PPE family protein PPE10	nSNPs	+	+

^aNon-synonymous SNP
^bSynonymous SNP

Back to article page

ISSN: 1471-2164

Contact us

Submission enquiries: bmcgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com