Fig. 4

Protein-protein interaction network analysis of the differentially abundant proteins. Network clusters are given for N = 64 proteins which were down-regulated in poor quality (BQ) eggs and N = 51 proteins which were up-regulated in BQ eggs. The subnetworks formed by proteins down-regulated in BQ eggs are shown to the left of the bold diagonal dashed line, and the subnetworks formed by proteins up-regulated in BQ eggs are shown to the right of this line. Where possible, finely dashed lines encircle clusters of interacting proteins involved in physiological processes distinct from other such clusters. Network nodes (spheres) represent all proteins originated from a single, protein-coding gene locus excluding splice isoforms or post-translational modifications, and each are named for the human proteins to which spectra were mapped (see Table S2 for full protein names). Specific and meaningful protein-protein associations are indicated by edges (colored lines). Model statistics are presented at the top left and at the top right of the figure for proteins down- and up-regulated in BQ eggs, respectively. Images used in this figure were obtained from STRING a free biological database and web source for predicted protein–protein interactions analyses and they are not subject to copyright