Fig. 2

Expression variation of myosin heavy chain (Myh), muscle ankyrin repeat proteins (MARP-CARP(Ankrd1)/ARPP(Ankrd2)/DARP(Ankrd23)), titin (Ttn), Caplain 3 (Capn3), myopalladin (Mypn), and Sarcolipin (Sln) genes in mdm vs wild-type muscles. a oxidative myosin heavy chains were preferentially expressed over glycolytic myosins in mdm EDL, psoas, and soleus but no significant expression difference was found in EDL at the 99% significant level. b CARP/Ankrd1 was > 18.7 fold upregulated in all three muscles. A significant expression difference of ARPP/Ankrd2 was only observed in mdm EDL (p-adj < 0.01). DARP/Ankrd23 was downregulated in mdm psoas and soleus. c Titin was downregulated in both mdm psoas and soleus, but no significant expression difference was observed in mdm EDL at the 99% significant level. A 2.8-fold downregulation in Capn3 was observed in mdm EDL, psoas and soleus, but Mypn expression was consistent between genotypes. (*p-adj < 0.01). d Sarcolipin shows the largest expression change in fast muscles (log2 fold changes – EDL (8.6), psoas (8.9), soleus(3.9))