Fig. 4

Genes associated with cellular energy metabolism are correlated with the mdm genotype and are highly interconnected. a) Sample clustering shows no outlies in the dataset. Two major clusters separated mdm from WT samples, while replicates of each muscle group cluster with each other. b-c) Power screening for network construction. b) Scale free topology (network independence) fluctuation, and c) mean connectivity variation based on different power values. d) Heatmap of module eigengenes (ME) correlation to the genotype (mdm/wild type). In each cell, the p-values associated with the calculated correlation are enclosed in parentheses. Overview of pathway analysis associated with the differentially expressed genes in e) blue, and g) turquoise modules. Bars show the percentage of genes associated with each enriched pathway in the module as a fraction of total annotated genes. Adjusted p-value of selected terms are shown at the right side of the bars. Distribution of individual gene significance to genotype, and module membership of genes in f) blue, and h) turquoise module